Jacobs Journal of Clinical Case Reports

Successful Treatment of Behcet’s Disease Utilizing Bacterial and Viral Antigens

*Luke Curtis
Department Of Case Reports, United States

*Corresponding Author:
Luke Curtis
Department Of Case Reports, United States

Published on: 2017-10-25


Objective:To describe the successful therapy of a patient with Behcet’s disease using streptolysin O and other bacterial and viral antigens.
Methods:A 32 year-old man with a 24- year history of Behcet’s disease symptoms not alleviated by several standard treatments (methotrexate, azathioprine, and prednisone) is described. He was given a treatment regime that included antigens from Streptococcus,\other bacteria, viruses, and streptolysin O.
Results:After seven months treatment, the patient’s BD symptoms improved dramatically including almost total cessation of mouth andgenital ulcers, almost total disappearance of chronic pain, and significant increase in energy levels.
Conclusion:Treatment with antigens from Streptococcus and other common bacteria and streptolysin O may be useful in treating Behcet’s disease.


Behcet’s Disease; Chronic Fatigue; Streptolysin; Histamine; Streptococcus antigens


Behcet’s disease (BD) is a complex multi-system auto-inflammatory and autoimmune disease involving many organ systems [1, 2]. A majority of BD patients experience mucocutaneous problems such as oral and genital ulcerations, papulopustular skin lesions, and erythema-nodosum (EN) like skin lesions [3, 4]. Other common BD manifestations include eye difficulties such as uveitis [3], joint disorders [3], cardiovascular complications [3, 5-7], neurological and neuropsychiatric conditions such as hearing loss, depression and anxiety, cognitive function loss and hemiparesis [3, 8-12], and gastrointestinal problems such as diarrhea, GI pain, bleeding, and ulceration [3, 13, 14]. Other common health problems include chronic fatigue, sexual dysfunction, and significantly lower quality of life [10, 11]. BD is generally diagnosed by the presence of recurrent oral ulcers and two or more of the following features: genital ulcers, skin lesions, eye lesions, and positive pathergy test (pathergy test involves needle puncture) [3, 15]. BD development is believed to be related both to genetics (especially the human leukocyte antigen (HLA)-B51 allele) and possibly microbial factors such as the HSV-virus or Streptococcus [2-4].