Jacobs Journal of Clinical Case Reports

Two Cases of Gilles de la Tourette Syndrome in One Family

*Elena Ivanova
Department Of Case Reports, University Hospital “Alexandrovska” - Sofia, Bulgaria

*Corresponding Author:
Elena Ivanova
Department Of Case Reports, University Hospital “Alexandrovska” - Sofia, Bulgaria
Email:helen_aivan@abv.bg

Published on: 2019-01-20

Abstract

The article presents the cases of two half-brothers with Gilles de la Tourette syndrome and concomitant intellectual disability, manifestation of dysmorphic features (small upward slanting eyes, large low-set dysplastic ear auricles and short neck), and a family history of tics on their mother’s side – relatives with tics in their childhood. Tics and Tourette syndrome have been diagnosed only in male members of this family. The genetic screening performed in both patients did not find presence of the fragile X chromosome syndrome.

Keywords

Gilles de la Tourette syndrome, intellectual disability, fragile X chromosome.

Introduction

A multitude of motor tics and one or more vocal tics of childhood onset have been diagnosed in Tourette, occurring comparatively frequently with other concomitant mental disorders. Tourette incidence among the population ranges between 0.3 [1] and 1 per cent [2], the ratio males/females b?ing 3:1[1] according to some authors and 4.3:1[3,4] according to others. The results of family studies on patients with Tourette disclose a greater incidence of tics and Tourette among first-degree relatives, as compared to the families of healthy controls.