Jacobs Journal of Diabetes and Endocrinology

Improvement of glucose variability by continuation of Low-Carbo meal

*Hiroshi BANDO
Department Of Biochemistry, Tokushima University, Tokushima, Japan, Japan

*Corresponding Author:
Hiroshi BANDO
Department Of Biochemistry, Tokushima University, Tokushima, Japan, Japan

Published on: 2018-12-29


Background: For years, there have been various discussion of Calorie Restriction (CR) and low carbohydrate diet (LCD). We have continued clinical research of CR and LCD so far. Patient and Method: The patient was 72-year-old female with type 2 diabetes mellitus (T2DM). At first visit, she showed BMI 29.5, postprandial 120 min of blood glucose 548 mg/dl, HbA1c 18.0%, Hb 11.4 g/dL, GOT 29 IU/mL, r-GTP 36 IU/mL, Cre 1.0 mg/dL, TG 194 mg/dL, LDL 161 mg/dL. Serum C-peptide radioimmunoactivity (CPR) 5.4 ng/mL, urinary protein 24 mg/dL.

Results: We have treated her by standard LCD meal, including 26% of carbohydrate with 1400kcal per day. She could continue LCD successfully and showed the decreased data as follows: HbA1c 18.0% to 7.8%, blood glucose 548 mg/dL to 154 mg/dL, proteinuria 24 mg/dL to 3 mg/dL, weight 72 kg to 65 kg for some months.

Discussion and Conclusion: LCD showed clinical efficacy in several biomarkers. Patient applied standard-LCD method, including 26% of carbohydrate with 1400 kcal per day, which would bring decreased HbA1c, glucose, proteinuria and weight to the actual degree. These data would become basal reference and would bring further research development in the future.


Glucose variability; Type 2 diabetes mellitus (T2DM); Low-Carbo; standard-low carbohydrate diet (standard-LCD); Calorie Restriction (CR)


Recently, there has been serious medical and social problems worldwide. It is acute increase of type 2 diabetes mellitus (T2DM). The number of T2DM was approximately 385 million in 2014, and will increase to 592 million by 2035 [1,2]. Consequently, effective and successful treatment for T2DM has been in discussion for years, including diet therapy, exercise therapy, anti-diabetic agents and insulin therapy [3].