The Influence of Hashimoto’s Thyroiditis Lymphocytic Infiltration in BRAFV600E Mutation Positive Papillary Thyroid Carcinoma
*Mi Kyung Shin Department Of Pathology, Hallym University, South Korea, Korea, Democratic People's Republic Of
*Corresponding Author: Mi Kyung Shin
Department Of Pathology, Hallym University, South Korea, Korea, Democratic People's Republic Of Email:email@example.com
Published on: 2018-10-25
Background: Papillary thyroid carcinoma (PTC) and Hashimoto’s thyroiditis (HT) are frequently present together. BRAFV600E mutation may be associated with a more advanced PTC at diagnosis. We evaluated the influence of HT in BRAFV600E mutation positive PTC with clinicopathologic features. Methods: The study was performed on 66 PTC patients after surgical management from January 2012 to December 2012. BRAFV600E mutation analysis was performed by polymerase chain reaction (PCR)- based amplification of DNA extracted from paraffin-embedded tumor specimens.
Results: 24cases (36.4%) among 66 PTC patients had concomitant HT. Statistical analysis showed no significant difference between PTC with concurrent HT (PTCHT+) and without concurrent HT (PTCHT-) in several clincopathologic features (age, sex, size, multiplicity, lymph node metastasis and extrathyroidal extension). But some correlation was noted in female gender in PTCHT+(P-value; 0.082). BRAFV600E mutation was observed in 50 (75.8%) of 66 patients with PTC. 32 cases among 42 cases of PTCHT- and 18 cases among 24 cases of PTCHT+ showed BRAFV600E mutation. There was no significant difference between PTCHT+ and PTCHT- in BRAFV600E mutation rate. But in BRAF V600E mutaton positive PTC, PTCHT+ showed significant less frequent lymph node metastasis than PTCHT- (P-value; 0.035).
Conclusion: Some correlation was noted in female gender in PTCHT+(P-value; 0.082) although statistically not significant. There was no significant difference between PTCHT+ and PTCHT- in BRAFV600E mutation rate. But in BRAF V600E positive PTC, PTCHT+ showed significant less frequent lymph node metastasis than PTCHT- (P-value; 0.035)
PTC is the most common thyroid cancer and has been increased in number, worldwide. HT is the most frequently found autoimmune thyroid disease, and around two percent of the general population suffer from this disease. Ever since Dailey and his co-workers first discovered the relationship between HT and PTC in 1955, scholars started to pay increasing attention to this topic . However, the pathogenesis of PTC in HT patients still remains unclear. It is supported by a number of studies that patients with PTC have more HT prevalences than those with benign and other malignant thyroid tumors [3-4]. The frequency of the association between PTC and HT ranges from 10% to 58% .