Jacobs Journal of Emergency Medicine

Evaluation of the Efficacy of a Temporary Hemostatic Device in a Swine Model of Closed Lethal Liver Injury

Published on: 2014-12-06


Background: Closed intra-abdominal hemorrhage remains the increasing leading cause of death both on the battlefield of modern warfare and in the civilian environment.

Objective: Developing a temporary hemostatic device to control of closed intra-abdominal hemorrhage, and to determine the hemostatic effect in a swine model.

Methods: A swine model of closed, lethal liver injury was established. The animals were randomly divided into group A (blank control), group B (gauze pack), group C (intra-abdominal compression by the device), group D (drug injection by the device), and group E (drug injection and intra-abdominal compression by the device) with 4 swine per group. Survival time, blood loss, and vital signs were monitored for all groups, and histologic examination after death was performed. One swine in group E was given liver CT-enhanced-scan at 4-time points to observe the device application.

Results: Group E had a significantly longer survival time and less blood loss than groups A, C, and D, while there were no statistical differences between groups B and E, both of which had more stable mean arterial pressure and cardiac output curves after liver injury. A histologic examination after death revealed no obvious secondary injuries in other visceral organs. Liver CT-enhanced-scan showed that intrahepatic hemorrhage was controlled to a certain extent.

Conclusion: This device prolongs survival time and controls blood loss in a swine model of closed lethal liver injury, which is equivalent to the gauze packing under this model with no obvious thrombosis or embolus formation in other organs.


Closed intra-abdominal massive hemorrhage, Temporary hemostatic device, Liver injury model