Radiomitigative Effects of Grifola frondosa Preparations on Mice Exposed to Lethal Ionizing Irradiation
Published on: 2018-02-26
Maitake mushroom Grifola frondosa (GF) is a polyporaceous fungus, increasingly recognized as a good source of polysaccharide compounds with dramatic health-promoting potential. To examine the radiomitigative effect of GF, we tested the effect of seven preparations of this fungus on the survival of mice exposed to lethal ionizing radiation. We tested freeze-dried fungal body of GF (YM-6A), α-glucans obtained from YM-6A (YM-2A), fiber components of GF (YM-11), GF mycelium (YM-51), hot-air dried ingredients (MD), 1:1 mixture of MD and YM-6A (YM-52), and crystal ergothioneine (YM-44). Each preparation was administered orally to 8-week-old mice for 7 consecutive days at 10 mg/kg/day before X-irradiation. All non-treated individuals died by day 16. The survival rate among the mice treated with YM-6A was 20% on day 30. One YM-52-treated mouse also survived until day 28. However, other preparations (YM-2A, YM-11, YM-44, and YM-51) had no radiomitigative effect. None of the substances used in the study affected the growth of non-irradiated control mice, demonstrating that these preparations were not toxic. We conclude that GF can be ingested with daily food and some of the preparations can counteract the harmful effects of radiation exposure, such as low-dose, long-term exposure.