Jacobs Journal of Genetics

Autism, Still A Medical Mystery? Running Title: Autism Spectrum Disorder (ASD) and Genetic Features: Importance in Clinical Medicine!

Published on: 2016-07-01


In 1943, the well-known child psychiatrist, Leo Kanner, announced his discovery of eleven cases of a new mental disorder [1]. He noted that «the condition differs markedly and uniquely from anything reported so far...»This condition soon became known as autism. Autism spectrum disorder (ASD) is defined by impaired social interaction as well as impaired language and communication accompanied by stereotyped/heartbreaking behavioral traits and increased restricted repetitive behaviors [2]. ASD describes a range of conditions (e.g. autism, social and communication deficits, Asperger disorder, childhood disintegrative disorders, pervasive developmental disorders, and rare syndromes such as such as fragile X and Rett syndrome) [3] classified as neurodevelopmental disorders in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) (http://www.dsm5.org/Pages/Default.aspx).