Assessment of Antioxidant Micronutrients Levels in HIV/AIDS Patients in Sokoto, North Western Nigeria
Published on: 2017-09-15
Background: HIV/AIDS patients are under chronic oxidative stress and may play a critical role in the pathogenesis and chronic complications of HIV/AIDS. Micronutrients may play an important role in the management of HIV/AIDS patients.
Objective: The current study is aimed at assessing the serum antioxidant micronutrients levels in 50 controls and 200 HIV-positive adult patients attending Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, Nigeria.
Materials and Methods: Participants were recruited in the Antiretroviral Therapy (ART) Clinic, Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto. CD4 cell count was enumerated using flow cytometric method, Body mass index (BMI) was calculated using weight (Kg)/height (M2), while serum concentrations of antioxidant minerals, Copper (Cu), Zinc (Zn), Manganese (Mn) and Selenium (Se) were measured using atomic absorption spectrophotometric method.
Results: In HIV-positive HAART-naive the levels of the analytes were: Cu-17.18±0.18 µmol/l, Mn-1.07±0.02 µmol/l, Se0.28±0.01 µmol/l, Zn-13.45±0.10 µmol/l; CD4 Count-504.69 ±13.51 cells/l and BMI were 23.51±0.44 Kg/m2. In HIV-positive on HAART the levels were: Cu-17.37±0.78 µmol/l, Mn-1.25±0.05 µmol/l, Se-0.28±0.01 µmol/l, Zn-13.60±0.13 µmol/l; CD4- 624.73±23.24 cells/l and BMI-25.58±0.55 Kg/m2. In Controls the levels were: Cu-19.97±0.25 µmol/l, Mn-1.68±0.07 µmol/l, Se-0.38 ± 0.01 µmol/l, Zn-16.51±0.21 µmol/l; CD4-952.02±39.15 cells/l and BMI-24.45±0.63 Kg/m2. With the exception of BMI, there were statistically significant differences between the HIV patients and Controls (p<0.05). The results indicated that HIV- positive patients were deficient in the vital micronutrients. A further study currently in progress will further evaluate whether supplementation with these nutrients will replenish the body micronutrient contents for improved treatment plans of HIV patients.