Jacobs Journal of Materials Science

Modification of Solid Lipid Nanoparticles for Drug Delivery

Published on: 2018-05-03


Solid lipid nanoparticles (SLNs) have been widely studied and considered as potential nano based-system in drug delivery. Composing of lipid components that are solid at room and body temperature, they have many desirable characteristics such as non-toxic nature, stability, biocompatibility and biodegradability, etc. For those reasons, SLNs have significantly attracted attention in pharmaceutical fields, especially, in the production, modification, and characterization using different techniques. Accordingly, this review provides an update on appropriate modification methods of SLNs, which can be listed as a sophisticated process on (1) surface modification including positive modification and targeting modification, (2) surfactant modification, and (3) lipid modification. Furthermore, future prospects and perspectives associated with SLNs will also be discussed in the scope of this review.


Solid lipid nanoparticles; Positive charge; Surface modification; Positive modification; Modification for targeting; Surfactant modification; Lipid modification