Jacobs Journal of Medicinal Chemistry

Synthesis of New Bis-Triazole Compounds Including Schiff Bases and Enzyme Inhibition and Antioxidant Activities

Published on: 2017-03-16


Compounds 1 and 2 possessing bis-triazole rings were reacted with four aromatic aldehydes and compounds 3-4(a-d) carrying Schiff bases were synthesized. All newly compounds well characterized by spectroscopic data such as FT-IR, 1 H NMR, 13C NMR, LC-MS/MS, and elemental analyses. All the newly synthesized compounds were screened for their enzyme and antioxidant activities. This study was explained the acetylcholinesterase/butyrcholinesterase and tyrosinase inhibitory effects, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and phosphomolydenum reducing antioxidant power of the newly synthesized compounds for the first time. While compound 4a might be effective neurological agent, compounds 3c and 4c have antioxidant potential.


Bis-Triazole; Schiff Base; Antioxidant; Enzyme Activities