Synthesis of New Bis-Triazole Compounds Including Schiff Bases and Enzyme Inhibition and Antioxidant Activities
* Dr. Yasemin Ünver Department Of Chemistry, Trabzon, Turkey
*Corresponding Author: Dr. Yasemin Ünver
Department Of Chemistry, Trabzon, Turkey Email:firstname.lastname@example.org
Published on: 2017-03-16
Compounds 1 and 2 possessing bis-triazole rings were reacted with four aromatic aldehydes and compounds 3-4(a-d) carrying Schiff bases were synthesized. All newly compounds well characterized by spectroscopic data such as FT-IR, 1 H NMR, 13C NMR, LC-MS/MS, and elemental analyses. All the newly synthesized compounds were screened for their enzyme and antioxidant activities. This study was explained the acetylcholinesterase/butyrcholinesterase and tyrosinase inhibitory effects, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and phosphomolydenum reducing antioxidant power of the newly synthesized compounds for the first time. While compound 4a might be effective neurological agent, compounds 3c and 4c have antioxidant potential.
Antioxidants have capacity to protect organisms and cells from damage caused by oxidative stress during metabolism. For this reason, the synthetic compounds are extensively studied for their antioxidant activities using different methodologies. The search for active components that prevent or reduce the impact of oxidative stress on cells is a quite contemporary field. Exogenous chemicals involved in food systems and endogenous compounds involved in metabolic processes in human body produce highly reactive free radicals, particularly oxygen derived ones. They have the potential to oxidize biomolecules and cause cell death, consequently causing tissue damage. It is known that free radical oxidative processes also play a significant pathological role in causing many human diseases together with aging [1-2]. As oxidative stress plays an important role in Parkinson, Alzheimer, heart failure and cancer, the use of antioxidants is intensively studied in medicinal chemistry, particularly as a means for the treatment of these widespread diseases [3-7].