Jacobs Journal of Nephrology and Urology

Histopathological Findings of Patients with Type 2 Diabetes Undergoing Kidney Biopsy: Diabetic Nephropathy versus Non-Diabetic Kidney Disease

Published on: 2019-03-15

Abstract

Aim: Kidney diseases are common among diabetes mellitus (DM) patients, including diabetic nephropathies (DN) and non-diabetic kidney diseases (NDKD). The clinical differentiation among them is usually not so clear. This study examined kidney biopsies in patients with type-2-DM who underwent native kidney biopsy. Materials and Methods: We analyzed retrospectively the reported histopathological findings of kidney biopsies obtained from 51 type-2-DM patients who underwent native kidney biopsy in our center between January 2005 and December 2016. Routine processing of kidney biopsies includes evaluation by light microscopy, immunofluorescence and electron microscopy. Results: There were a total of 51 DM patients, 28 males (54.9%) and 23 females (45.1%). The mean age was 50.8 (47.1-55.2) years, 86% of patients were between 25 and 64 years old. Histological findings showed that 43.1% of patients had diabetic nephropathy. While focal segmental glomerulosclerosis was present in 23.5%- primary in 9.8% and secondary in 13.7%. Lupus nephritis and drug induced interstitial nephritis were each present in 5.8%. MCD and IgA nephropathy were each present in 4%. Lastly membranous nephropathy, diffuse proliferative GN, ANCA associated glomerulonephritis, hypertensive nephrosclerosis and others accounted for 2%. Conclusion: This is the first study of its kind in Oman covering a period of more than ten years and is representative of the whole country. It showed that the prevalence of NDKD is remarkably frequent in DM patients in whom nephrologists consider kidney biopsy to be an appropriate measure. Among NDKD, FSGS was the most frequent diagnosis.

Keywords

Diabetic Nephropathy, Diabetic Kidney disease, Diabetes mellitus, Sultanate of Oman, Chronic kidney disease, Estimated Glomerular Filtration Rate (e GFR)