Jacobs Journal of Obesity

Genetic Polymorphisms of Obesity-related Diseases

Published on: 2018-12-15


Obesity is a serious and urgent public health problem worldwide. Around one-third of the world’s pop-ulation is overweight. The prevalence of obesity has doubled in many populations, hindering several types of disease prevention, reducing the quality of life of patients and consequently increasing healthcare costs. As-pects of modern life such as globalization, sedentary lifestyle, high consumption of processed food and high-cal-orie food intake have significantly contributed to increase the prevalence of obesity-related diseases. Obesity is a multifactorial disease and its onset is linked to genetics, epigenetics, behavioral and economic traits. Severe obesity individuals are at greater risk of developing coronary artery disease, hypertension, type 2 diabetes, os-teoarthritis, several types of cancer, such as breast and endometrial cancers, and eventually premature death. The present systematic review highlights the relationship between genetic polymorphisms and obesity-related diseases. We concluded that innumerous polymorphic genes might increase the prevalence of such diseases in obese patients.


Obesity; Obesity-Related Diseases; Genetic Polymorphisms