Jacobs Journal of Organic Chemistry

New Approaches for the Synthesis of Thiophenes, Thiazole, Pyran Derivatives, and their Antitumor Evaluation

Published on: 2017-11-01


This research aims to a novel synthesis of thiophene, pyrans, azoles and azines derivatives in which we started with cyclopentanone as starting material which reacted with malononitrile and ethyl cyanoacetate. The synthesized compounds were confirmed by spectral and analytical data. The biological evaluation of compounds are tested on three different tumor cell lines such as breast adenocarcinoma, CNS cancer, and non-small lung cancer and was compared to the inhibitory effect of Doxorubicin. And the results revealed that compounds 7, 13b and 17b have the highest inhibitory effect.


Thiophene; Pyrazole; Pyrane; Pyridine; Cytotoxicity