Jacobs Journal of Organic Chemistry

Synthesis of Pyran, Pyridine, Thiophene, Pyrimidine and Thiazole Derivatives with Antitumor Activities

Published on: 2017-02-16


The aim of present study was the uses of 4- methyl cyanoacetanilide (1) in the synthesis of pyridine, pyran, thiophene, thiazole, pyrimidine, chromen derivatives together with their antitumor evaluations. The work has resulted in the synthesis of a variety of 2- aminopyran, 2- hydroxypyran, 2-amino pyridine, 2-hydroxypyridine, 4,5,6,7-tetrahydrobenzo[b]thiophene, N-benzal,N-acetyl, N-phenylthiourea, thiazole, pyrimidine, phenylhydrazone, benzalydine, ethoxyethine and N- phenylmethino derivatives. The antitumor activities of the newly synthesized product were evaluated against cancer.


Pyridine; Pyran; Thiophene; Pyrimidine; Antitumor Activities