Jacobs Journal of Plant Biology

Effect of Different Concentrations of Some Medicinal Plant Extracts on Sensitivity and Viability Count of Candida Albicans (As In Vitro Study)

*Taisir Khaleel Ismael. B.T
Department Of Plant Biology, King Khalid University, Kuwait

*Corresponding Author:
Taisir Khaleel Ismael. B.T
Department Of Plant Biology, King Khalid University, Kuwait
Email:tayseerkhalil413@gmail.com

Published on: 2019-06-29

Abstract

The antifungal effect of some medicinal plant extracts (peppermint and pomegranate) was confirmed by some studies. However, there was still a lack of knowledge regarding the specificity of these extracts on sensitivity and viability counts of candida albicans, so for this reason this study was conducted. Water extract (peppermint and pomegranate) was prepared, different concentration (5, 10, 15, 20, and 25 mg/ml) from them were taken, tested candida albicans was used to evaluate these extracts on its sensitivity and viability counts (in vitro). Result showed that all concentration of pomegranate showed zone of inhibition, the zone were increased when concentration of extract was increased, but peppermint revealed zero zone of inhibition on Sabouraud dextrose agar medium. All concentrations of both extracts were effect in reducing viability counts of candida albicans with statistically significant differences with control P<0.05, 25% pomegranate extract and 20% peppermint recorded the maximum mean value in reduction the number of candida albicans. The differences were not significant (P>0.05) for all concentrations of pomegranate and peppermint with each other’s except for 25% concentration there was significant difference P<0.05.

Keywords

Candida Albicans ; Viability Count; Medicinal Plant Extracts; Different Concentrations

Introduction

The fungus Candida albicans is a commensal organism of the mucosal microbiota in the oral cavity, gastrointestinal and genitourinary tracts, presenting ability to switch reversibly between yeast, pseudohyphal, and hyphal growth forms. This polymorphism is one of the most investigated virulence attributes in mucosal infections and disseminated infections affecting susceptible individuals [1].