Jacobs Journal of Psychiatry and Behavioral Science is committed to publish leading articles related to the disciplines of psychiatry like branches of psychiatrics, Psychotherapy, Addiction psychiatry, Biological psychiatry, Forensic Psychiatry, Social Psychiatry, Stress, Psycotrauma, Child and Adolescent Psychiatry.
Jacobs Journal of Psychiatry and Behavioral Science is committed to publishing leading articles related to the disciplines of psychiatry like branches of psychiatric, Psychotherapy, Addiction Psychiatry, Biological Psychiatry, Forensic Psychiatry, Social Psychiatry, Stress, Psycotrauma, Child and Adolescent Psychiatry.
Journal of Psychiatry and Behavioral Science Volume 1 Issue 1 published articles discussing Attenuation of Anxiety/Depression-like Behaviors and Neuroanatomical Changes Following Quercetin and Rutin Exposure in Zebrafish (Danio rerio) , and Does Major Depression and its Treatment Affect Platelet Activity? .
The flavonoids quercetin and Rutin, present in a variety of fruits, vegetables, and medicinal plants such as St. John’s wort (Hypericum perforatum), are known to have wide-ranging beneficial effects on human health. The aim of this study by Julian Pittman et al. ., is to clarify the mechanisms-of-action underlying changes in anxiety/depression-related behaviors and the neuroanatomical components affected following exposure to quercetin and Rutin in zebrafish (Danio rerio). The author employed behavioral and histological analysis, behavioral improvement similar to that of fluoxetine treatment and significant upregulation of hippocampal serotonergic and dopaminergic neurons is observed in zebrafish treated with both quercetin and Rutin. It is indicated, based on the results of this study, that quercetin and Rutin mediate their antidepressant effects through dopaminergic and serotonergic neurotransmission and that dietary quercetin and Rutin are promising as antidepressant-like compounds, and possible neuroactive pharmaceutical lead structures. Therefore, further investigations of these and additional secondary plant metabolites for potential antidepressant properties are needed.
This study was undertaken BY John Piletz et al. ., to test the prevailing hypothesis that depressive illness is associated with platelet hypercoagulability and/or activation. A second hypothesis is that escitalopram treatment would attenuate these measures by 12 weeks, though probably not by 8 weeks of treatment. Platelets from untreated patients were not different from controls by flow cytometry (i.e., P-selectin surface labeling) but tended towards higher agonist-free PRP aggregation. Escitalopram treatment lowered agonist-free aggregation by 8 weeks. Agonist induction by ADP is non-discriminative in platelet group responses at pre-treatment, but by 12 weeks on escitalopram, the ADP-induced surface P-selectin is downregulated with an up-regulation of ADP-induced PRP aggregation. However, during all phases of the study, there were negative associations between mood rating scales and platelet reactivity. Hence, the first hypothesis is not confirmed that untreated depression would be associated with higher platelet reactivity. However, escitalopram lowered certain aspects of platelet reactivity. Treatment with an SSRI, therefore, appears to have complex effects on platelets depending on which measure is studied.
For more information: https://jacobspublishers.com/ june-2015-volume-1-issue-1-psychiatry-and-behavioral-science/
The Journal welcomes articles from all the fields related to Psychiatry and Behavioral Science.
1.Julian Pittman*, Kirsten Henry, Christopher Kelly, Michael Wayne Morris. Attenuation of Anxiety/Depression-like Behaviors and Neuroanatomical Changes Following Quercetin and Rutin Exposure in Zebrafish (Danio rerio).
2. John Piletz, PhD, Edwin Meresh, MD, Debra Hoppensteadt, PhD, Walter Jeske PhD, Jawed Fareed, PhD, James Sinacore, PhD, C. Lindsay Devane, PhD and Angelos Halaris, MD PhD. Does Major Depression and its Treatment Affect Platelet Activity?