Jacobs Journal of Vaccines and Vaccination

The Rational for Auto Vaccines in Poultry Colibacillosis

Published on: 2018-10-24

Abstract

Colibacillosis is a rather important economic problem for poultry production, associated to Avian Pathogenic Escherichia coli (APEC) strains, which may cause several extraintestinal pathologies, such as airsacculitis and cellulitis in broiler chickens, and salpingitis and peritonitis in broiler breeders, leading to septicemic mortality. Control of morbidity and mortality in colibacillosis outbreakes may be performed with antibiotics and/or by vaccination. The use of antibiotics is frequently ineffective as Escherichia coli (E. coli) is considered the largest reservoir of antimicrobial resistance, characteristic that may even transmit to other bacteria, turning the situation into a serious problem of public health. Vaccination may be the alternative solution but as many different strains arise, flock-specific autovaccines seem to be needed under several possible protocols, with live attenuated and/or inactivated vaccines from different strains that should be identified and characterized according to their virulence factors, within different flocks.

Keywords

Colibacillosis; Avian Pathogenic Escherichia coli (APEC); autovaccines; live-attenuated; inactivated; virulenceassociated genes (VAGs)