Journal of Molecular Biomarkers and Clinical Trials

Alopecia Areata: Pathophysiology, Diagnosis, and Treatment

Published on: 2015-03-05

Abstract

Alopecia areata is a type of non-scarring hair loss resulting from an autoimmune response towards the hair follicle, with genetic and environmental factors playing significant roles. It has a chronic, relapsing course and is a frequent complaint encountered in the dermatologic practice. However, the treatment options currently available have variable efficacy, and none are curative. In order to provide better treatment options, extensive research on the disease pathophysiology is being performed. In this comprehensive review article, we discuss the disease clinical presentation, pathophysiology, relevant animal models and current and potential treatment options for further investigation.

Keywords

Abatacept, Alopecia Areata, Jak Inhibitors, Methotrexate, Phenol, Platelet Rich Plasma, Quercetin, Stat, Statins