Journal of Molecular Biomarkers and Clinical Trials

Association between the 8-OHdG Level in Placental/Umbilical Cord Blood and Maternal/Neonatal Characteristics at Full-Term Birth

Published on: 2018-06-02

Abstract

The aim of this study was to estimate the relationship between the levels of a DNA damage biomarker, 8-hydroxy-deoxyguanosine (8-OHdG), in placental/umbilical cord blood (CB) and maternal/neonatal characteristics at full-term birth.

Methods We used ELISA kits to measure the 8-OHdG levels in CB in mothers with full-term normal vaginal deliveries. The possible relationships between the 8-OHdG levels and infant birth weight, placental weight and placental weight per infant birth weight were assessed.

Results The 8-OHdG levels in the CB ranged from 0.11 to 1.19 ng/ml, with a median of 0.41 ng/ml (mean: 0.43 ± 0.21 n/ml). Significant positive correlations were observed between the 8-OHdG levels and placental weight or placental weight per infant birth weight (r=0.343, p=0.007, r=0.368, p=0.004, respectively). However, no significant correlations were observed between the 8-OHdG levels and infant birth weight. In addition, when the maternal body mass index (BMI) values were classified into three groups, significant positive correlations were observed between the 8-OHdG levels and placental weight per infant birth weight in the BMI 18.5–25 group and between the 8-OHdG levels and placental weight in the BMI ≥ 25 group.

Conclusions These findings demonstrate the possibility that the 8-OHdG level in CB is correlated with placental growth and suggest that the maternal physique affects this correlation

Keywords

Oxidative Stress; 8-OHdG; Placental/Umbilical Cord Blood; Body Mass Index; Placenta