Journal of Molecular Biomarkers and Clinical Trials

Clinical Trials Recruitment Challenges

Published on: 2015-09-22

Abstract

Recruitment is a challenging phase of clinical trials due to its relevance to research success. Failure in reaching recruitment goals might implicate in trials early termination, loss of statistical power and financial wastes. For the well-trained research centers there are several key points that might be addressed as recruitment challenges: first, finding new trials in the site therapeutic area and getting proper approval at local Institutional Review Board; secondly, having a self-sustainable research institution that can hire and train high qualified staff, and lastly, getting and retaining the potential patient the consent in participating. Mistrust, communication, and cultural barriers are common reasons why patients decided not to enroll. On the other hand, altruism, access to better care and closer clinical monitoring are common motives to consent. Understanding reasons why patients decide to participate or not in clinical trials can reduce the evident gap between registered trials and studies with posted results. The objective of this work is to discuss the recruitment challenges; it’s reasons and implications as well as share our barriers and strategies.

Keywords

A clinical trial, Registered trials, Physical fragilities, Visual and hearing deficits