Journal of Molecular Biomarkers and Clinical Trials

In Non-Small Cell Lung Carcinomas, 18f-Fdg Suvmax Values are Independent of P63 Immunohistochemical Expression

Published on: 2016-07-20

Abstract

Objective: to study the possible relation between immunohistochemical expression of p63 and the maximum standardised uptake value (max SUV) of 18F-FDG PET in patients with non-small cell lung cancer (NSCLC) Material and Methods: The study group included 49 patients (42 males), ranged between 41 to 82 years old with pretreatment NSCLC (26 squamous, 15 adenocarcinomas and 8 large cell carcinomas) of whom the diagnosis was found in our centre. According to the clinical stage the classification was the following: 2 IA, 9 IB, 1 IIA, 5 IIB, 9 IIIA, 10 IIIB and 13 IV. Immunohistochemical expression of p63 was studied through the technique of tissue-matrix using Tissue Arrayer Device (Beecher Instruments, Sun Prairie, WI), using the Mab Clone 4A4 from Dako (Denmark). Results: Positive p63 immunohistochemical expression was more frequent (p:0,0007) in squamous cell carcinomas (21/26; 80,7%) than in adenocarcinomas (2/15; 13,3 %), but not than in large cell carcinomas (4/8; 50%). There were not statistically significant differences on SuV max values in the patients classified according to p63 expression. The same findings were noted using different maxSuV qualitative cut-offs. When we considered exclusively the squamous cell carcinomas, we didn’t observe statistically significant differences between the maxSuV values (qualitative and quantitative) of patients classified according to p63 expression also. Conclusions: These results led us to consider that SuV max values are not correlated with immunohistochemical expression of p63 neither in patients with NSCLC considered as a whole nor in squamous cell carcinoma subtype, strong related to p63.

Keywords

p63, Non-Small Cell Carcinomas, maxSuV-18F-FDG-PET