Journal of Molecular Biomarkers and Clinical Trials

RDW is a Novel Prognostic Parameter in Diffuse Large B Cell Lymphoma in the Rituximab Era

Published on: 2017-01-29

Abstract

After the invention of rituximab, RCHOP became the standard regimen for Diffuse Large B cell lymphomas (DLBCL). Some patients still have a poor prognosis. Recent researches on Non-Hodgkin lymphoma has been related with prognostic biomarkers. Elevated RDW is accepted as a worse prognostic factor in some situations and diseases but the prognostic value has not been studied in DLBCL. The aim of this study was to investigate the prognostic role of RDW in DLBCL. Clinical and laboratory data from 217 DLBCL patients were retrospectively studied in a single center by multivariate analysis, Kaplan-Meier survival analysis, forward stepwise and Cox regression analysis were used to examine the effect of RDW on survival. In this data set, elevated RDW levels were strongly associated with shorter survival. RDW was determined as a predictor of mortality and seems to be a simple, cost-effective novel prognostic parameter in DLBCL in the rituximab era.

Keywords

Erythrocytes; Chemotherapy; Lymphoma; RDW; Prognostic; Biomarker