Journal of Molecular Biomarkers and Clinical Trials

Which biomarkers to evaluate the association between psychosocial factors and neuro-cardiovascular diseases?

Published on: 2018-12-24


The association between psychological factors and neuro-cardiovascular diseases had been suggested. This review was performed to assess, from the results of literature, the pertinence of using new biomarkers in the occurrence of neuro-cardiovascular diseases in a psychosocial context. We chose to consider wide-ranging descriptions of stress from psychological factors (occupational stress, financial strain, marital stress, social isolation) that may influence a physical health outcome (stroke, cardiovascular diseases) through a psychological mechanism. We addressed literature data confirming the link between new biomarkers such as cortisol, endothelial dysfunction, inflammation, and allostatic load in neuro-cardiovascular diseases related to psychological factors. First, it was shown a link between deleterious effects of cortisol and the occurrence of neuro-cardiovascular diseases in a psychosocial context. Second, endothelial dysfunction (flow mediated dilation of the brachial artery) is observed in association with job strain and occupational category. Stressful events and distress can also substantially increase the production of pro-inflammatory cytokines. Finally, increased allostatic load is associated with higher job demands in industrial workers, lower decision latitude and job strain in healthy workers, burnout and career instability, effort-reward imbalance and exhaustion. All the papers included in this review confirmed the link between neuro-cardiovascular diseases occurrence in a psychosocial context and these biomarkers.


Psychosocial factors, biomarkers, cortisol, endothelial dysfunction, inflammation markers, allostatic load, neuro-cardiovascular diseases.