Journal of Molecular Biomarkers and Clinical Trials

A Composite Biomarker Panel as a Highly Informative and Reliable Tool for Predicting Septic Complications

*Sergey Suchkov
Department Of Pathology, IM Sechenov First Moscow State Medical University, Russia , Russian Federation

*Corresponding Author:
Sergey Suchkov
Department Of Pathology, IM Sechenov First Moscow State Medical University, Russia , Russian Federation
Email:ssuchkov57@gmail.com

Published on: 2018-06-03

Abstract

Due to growing antibiotic resistance and poor early diagnosis, sepsis remains a formidable infectious complication of many diseases, often leading to death. Immune quantitative formulas for prediction and septic complications diagnosis for burned patients have been developed and included as follow: systemic lymphocytes, natural killers, HLA-DR+ monocytes, IgG deficiency, excessive activation of leukocyte intoxication index (LII), CD64+ of granulocytes and shift of hematologic state to the left. They allow prediction of septic complication of burn disease from several days to two weeks before establishing disease.

Keywords

Burns; Biomarkers; Immune Diagnostics; Prediction; Sepsis

Introduction

Sepsis is the most frequent and severe infectious complication in burn patients, which quite often leads to lethal outcomes. In various burn centers all over the world the majority of deaths of such patients were precisely caused by sepsis. Analysis of sepsis dynamics between 1979 and 2000 captured over 10 million 300 thousand cases of sepsis in U.S.