Journal of Molecular Biomarkers and Clinical Trials

Biomarkers for the Neglected Chagas Disease: How Remarkable!

*Dr. Paulo RZ. Antas
Department Of Molecular Biomarkers, Instituto Oswaldo Cruz, Rio De Janeiro, Brazil

*Corresponding Author:
Dr. Paulo RZ. Antas
Department Of Molecular Biomarkers, Instituto Oswaldo Cruz, Rio De Janeiro, Brazil
Email:pzuquim@ioc.fiocruz.br

Published on: 2016-05-09

Abstract

Chagas disease or American trypanosomiasis, caused by the etiological agent Trypanosoma cruzi, affects at least 8 million people in Central and South America. Morbidity is relatively high. The acute phase is followed by an asymptomatic phase, but roughly 30% of infected patients change to a symptomatic, chronic phase characterized by either severe cardiac or digestive forms.

Keywords

Parasitological, Trypanosoma cruzi, Inflammation and cellular injury biomarkers, Metabolic biomarkers, Prothrombotic biomarkers, Antigenic biomarkers

Introduction

Chagas disease or American trypanosomiasis, caused by the etiological agent Trypanosoma cruzi, affects at least 8 million people in Central and South America [1]. Morbidity is relatively high. The acute phase is followed by an asymptomatic phase, but roughly 30% of infected patients change to a symptomatic, chronic phase characterized by either severe cardiac or digestive forms [2,3]. Therefore, the identification of reliable indicators of Chagas disease pathology, such as biomarkers or biosignature profiles, would enable prioritization of treatment to those with the highest probability contracting this disease. In fact, those candidates may have diagnostic and prognostic power in patients with several forms of Chagas disease. Predicting factors that correlate with disease progression, morbidity and mortality to help in decision-making, follow-up and management of this complex disease is challenging. Simple, quantitative and inexpensive biomarkers, which add value to conventional approaches, are required to help in diagnosis and prognosis of patients with heart failure.