Journal of Molecular Biomarkers and Clinical Trials

Review of the Literature: Sepsis and Neutrophil Cd64

*Silvana Teixeira Dal Ponte
Department Of Emergency, Hospital Of Clinics Of Porto Alegre, Brazil

*Corresponding Author:
Silvana Teixeira Dal Ponte
Department Of Emergency, Hospital Of Clinics Of Porto Alegre, Brazil
Email:sildalponte@gmail.com

Published on: 2017-04-05

Abstract

Sepsis is a systemic inflammatory response against suspected or documented infection. In an infectious process, inflammation is triggered activating leukocytes, mainly neutrophils. CD64 is a surface antigen weakly expressed on non-activated mature neutrophils. When neutrophil CD64 is strongly expressed on neutrophils, it means neutrophils were activated, thus suggesting the presence of bacterial infection or acute fungal infection. A large number of biological substances has been investigated as candidate biomarkers and/or mediators of sepsis. Recent studies have focused on the investigation of neutrophil CD64 as a possible biomarker for the diagnosis of sepsis.

Keywords

Sepsis; SIRS; CD64; Biomarker

Introduction

The inflammatory process is a normal response to trauma, infection, or injury. Inflammation may present as a local or systemic manifestation. The systemic inflammatory response syndrome (SIRS) is a complex pathophysiological response to different types of injuries. Its main complication is the multiple organ dysfunction syndrome (MODS), a condition showing high rates of mortality.