Journal of Molecular Biomarkers and Clinical Trials
Why Should we Start Biomarker Study in Urine?
*Dr. Youhe Gao Department Of Biochemistry And Molecular Biology, Beijing Key Laboratory, Gene Engineering And Biotechnology, Beijing Normal University, Beijing, China
*Corresponding Author: Dr. Youhe Gao
Department Of Biochemistry And Molecular Biology, Beijing Key Laboratory, Gene Engineering And Biotechnology, Beijing Normal University, Beijing, China Email:email@example.com
Published on: 2015-12-17
Firstly, urine has more changes. It is cruel that winner takes all. It happens in lots of games. It may happen in biomarker field too. It may not happen yet, because it has been hard to find any significant changes in blood, which can be used as candidate biomarkers. In urine it is not difficult to find changes, even though not all the changes are associated with the targeted pathophysiological condition. If we introduce a change into the blood, the homeostatic mechanisms will try hard to remove it from the blood. The change can then go to urine, breath, sweat and bile. Those are all greater places to find biomarker than blood. Urine is free from contamination, it is the ideal place to find biomarkers
Homeostatic mechanisms, Biomarker Study in Urine, Breath, Sweat, Bile
potential biomarkers need to be validated in clinical samples. Biomarker study is not cheap, especially if the study starts with clinical samples which cannot be obtained completely harmless to the patients such as blood. It is much easier to receive permission to take urine samples than blood samples from patients. It is hard to take a lot of blood from a patient. But the quantity of urine you can take is almost unlimited with no harm as long as you can wait.Urine is easier to be stored now. It used to be hard to store before it takes much bigger space in the freezer. And proteins and nucleic acids in urine are not completely stable in aqueous solution no matter how cold you freeze it. But when the urinary proteins  and microRNA  can be adsorbed onto membranes and dried and kept dried in a vacuum bag, they are very stable even at room temperature.