Journal of Molecular Biomarkers and Clinical Trials

Wnt and Notch Signaling Pathways are Involved in the Development of Aggressive Salivary Gland Neoplasms

*Rizwan Masood
Department Of Otolaryngology, University Of Southern California , USA, United States

*Corresponding Author:
Rizwan Masood
Department Of Otolaryngology, University Of Southern California , USA, United States
Email:masood@med.usc.edu

Published on: 2017-10-04

Abstract

Salivary gland tumors are uncommon, however, the aggressive subtypes portend poor prognoses due to growth patterns, wide spread invasion, high incidence of local recurrence and distant metastases. An advance in the understanding of tumorigenesis is imperative to determine potential targets for therapy.

Keywords

: Salivary Gland Neoplasms; Wnt Signaling Pathway; Notch Signaling Pathway

Introduction

Tumors of the salivary glands are relatively uncommon malignancies, representing only 11% of oropharyngeal neoplasms in the United States [1]. Salivary gland tumors consist of over 20 different histological subtypes [2] and can affect both the major salivary glands (parotid, submandibular, sublingual), as well as minor salivary glands throughout the oral cavity and oropharynx. Salivary tumors present with a wide range of biological behavior, from benign (oncocytoma, cystadenoma, pleomorphic adenoma) to highly aggressive (low grade acinic cell carcinoma, adenoid cystic carcinoma, and high grade mucoepidermoid carcinoma) with wide spread invasion, local recurrence, and distant metastases.