Volume 1 Issue 1

Volume 1 Issue 1



How Do Affective Temperaments Develop Into Bipolar Disorders?

Koji Hatano , Takeshi Terao*

Affective temperaments are considered to be antecedents or sub-syndromal manifestations of bipolar disorders. It is,however, unknown how these temperaments develop into bipolar disorders. We hypothesize that: just before the onset of bipolar disorder, the left medial frontal gyrus (MFG) of cyclothymic and/or hyperthymic healthy subjects may degenerate and shrink in volume concomitantly with its dysfunction, just after the onset of bipolar disorder, this change may involve the right MFG and bilateral anterior cingulate cortex, leading to dysfunction of prefrontal cortex, during the first episode of bipolar disorders, prefrontal dysfunction may involve limbic system, leading to dysfunction of prefrontal-limbic system, and  along with recurrences of bipolar disorders, the prefrontal-limbic system dysfunction may progress. On the basis of our neuroimaging findings of affective temperaments, we believe that these hypotheses warrant further investigation.


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Research Article

Suicidality – Medical Care and Treatment in a Legal Perspective – A Question of Suicide Prevention
Law Lotta Vahlne Westerhäll*

The present work is enquiring into the legal implications of suicide and suicidality in Swedish health and medical legislation. Most people taking their own lives have been in contact with medical care before committing suicide, most commonly with psychiatric care or with general practitioners

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