Volume 2  Issue 2 

Volume 2  Issue 2

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Review Article

Radiographic Contrast Agents, Drugs Useful for Diagnostics, but with Contrast- Induced Nephropathy as Side Effect


Michele Andreucci*, Teresa Faga, Francesco Perticone, Ashour Michael
Iodinated radiographic contrast agents are drugs very useful in clinical practice to improve the visibility of internal organs and structures in X-ray based imaging techniques. Their use keeps increasing, particularly in less healthy and older patients, with one or more comorbid conditions, such as advanced vascular disease, severe long-standing hypertension, diabetes and impairment of renal function. However, they may have side effects the most frequent being Contrast-Induced Nephropathy (CIN).

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Research Article

Clinical Utility of Stool Culture in Targeting Antibiotic Prophylaxis for Transrectal Ultrasonography-Guided Prostate Biopsy

Satoru Minamida*, Yoshinori Taoka, Takefumi Satoh, Syoji Nagi, Syuhei Hirano, Masahiro Hagiwara, Teruaki Ao, and Masatsugu Iwamura
Escherichia coli is the pathogen most commonly associated with infections after transrectal ultrasonography-guided prostate biopsy, and the prevalence of fluoroquinolone-resistant E. coli is increasing. This study prospectively analyzed stool cultures, determined the presence of fluoroquinolone-sensitive (i.e., normal) and resistant E. coli, administered appropriate prophylactic antibiotics accordingly, and analyzed the rates of infectious complications following transrectal ultrasonography- guided prostate biopsy.

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Research Article

Plasma transforming growth factor-beta 1 and anti-HLA IgM antibodies affect the functional preservation of kidney allografts

Fumiya Obata*, Kazunari Yoshida, Yasuo Takeuchi, Makoto Kubo, Tadao Endo, Shiro Baba

To elucidate which of the plasma cytokines, interleukin-2 and interferon-γ, interleukin-4, interleukin-10, and transforming growth factor-β1, is most closely associated with the progression of chronic renal allograft injury (CRAI), we analyzed plasma from 87 patients who had undergone kidney transplantation. When the patients were classified into two groups based on the level of plasma creatinine, the transforming growth factor-β1 level was significantly higher in the normal creatinine group than in the high creatinine group.
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Research Article

Endostatin Co-Localises with MMP9- in the Renal Tubular Cells in an Experimental Model Ischemia/Reperfusion

Milena C. Cichy, Katiucia B. S. Paiva, Maria L. Z. Dagli, Daniel S. Sanches, Nestor Schor, Maria H. Bellini*

We have previously shown the expression of endostatin (ES) and matrix metalloproteinase-9 (MMP-9) in kidney in response to acute kidney injury induced by ischemia/reperfusion. The purpose of this research was to investigate the effect of renal ischemia/reperfusion injury on the expression and localisation of ES and matrix metalloproteinase 9 (MMP-9). C57BL/6 male mice were subjected to 45 minutes of ischemia and subsequent reperfusion (24, 48, and 72 hours). Renal function was evaluated based on blood urea nitrogen and creatinine dosage.

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