Lagenaria Breviflora is from the family Cucurbitaceae. Traditionally, it is useful in the treatment of human measles, digestive disorders and as wound antiseptics. The phytoconstituents present in the plant include triterpenoids, curcubitacin etc. Pharmacological study reported the anti-implantation, anti- bacterial, antiulcer, anti-inflamatory, antioxidant, Miracidal and Cercidal activity and antifertitlity. This review is an attempt to pin-point unexplored potential of the plant for further research.
Quantitative Determination of Free Calcium in Human Serum by High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
Xiangrong (Austin) Xu*, Kathryn Birkenbach
In a novel analytical method, ultra-filterable calcium concentrations in blood were determined using liquid chromatography/ tandem mass spectrometry (LC-MS/MS). Calcium present in blood serum of non-clinical adult males was analyzed following complexation with trans-1,2-diaminocyclohexane-N-N-N-N-tetraacetic acid monohydrate (DCTA). Results derived from this method demonstrated good agreement with accepted values for blood serum levels of ultra-filterable calcium, from which the concentration of physiologically-active ionized calcium may be estimated.
Systems Thinking for Medicinal Chemists
Robert E. Smith*, Kevin Tran, Kristy, M. Richards
Systems thinking has become an essential part of modern medicinal chemistry and new drug development. It is based on the concepts that complex problems almost always have multiple causes and that there are often connections that have not always been obvious. In contrast to reductionist thinking, systems thinking uses network theory and nonlinear mathematics to prevent, diagnose, treat and even cure diseases. Systems thinking is an integral part of predictive, preventive, personalized and participatory (P4) medicine.
Synthesis of New Bis-Triazole Compounds Including Schiff Bases and Enzyme Inhibition and Antioxidant Activities
Yasemin Ünver*, Fatih Çelik, Esra Düğdü, Burak Barut, Kemal Sancak
Compounds 1 and 2 possessing bis-triazole rings were reacted with four aromatic aldehydes and compounds 3-4(a-d) carrying Schiff bases were synthesized. All newly compounds well characterized by spectroscopic data such as FT-IR, 1H NMR, 13C NMR, LC-MS/MS, and elemental analyses. All the newly synthesized compounds were screened for their enzyme and antioxidant activities.