Volume 2 Issue 1

Volume 2 Issue 1

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Research Article
Attenuation of Anxiety/Depression-like Behaviors and Neuroanatomical Changes Following Quercetin and Rutin Exposure in Zebrafish (Danio rerio)

Julian Pittman1 *, Kirsten Henry1 , Christopher Kelly1 , Michael Wayne Morris1

The flavonoids quercetin and rutin, present in a variety of fruits, vegetables, and medicinal plants such as St. John’s wort
(Hypericum perforatum), are known to have wide-ranging beneficial effects on human health. The aim of this study was
to clarify the mechanisms-of-action underlying changes in anxiety/depression-related behaviors and the neuroanatomical components affected following exposure to quercetin and rutin in zebrafish (Danio rerio). Employing behavioral and
histological analysis, behavioral improvement similar to that of fluoxetine (Prozac®) treatment and significant upregulation of hippocampal serotonergic and dopaminergic neurons was observed in zebrafish treated with both quercetin and
rutin.

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Research Article
Does Major Depression and its Treatment Affect Platelet Activity?

John Piletz, PhD1, Edwin Meresh, MD2, Debra Hoppensteadt, PhD3, Walter Jeske PhD3, Jawed Fareed, PhD3, James Sinacore, PhD4, C. Lindsay Devane, PhD5 and Angelos Halaris, MD PhD2

This study was undertaken to test the prevailing hypothesis that depressive illness is associated with platelet hypercoagulability and/or activation. A second hypothesis was that escitalopram treatment would attenuate these measures by 12 weeks, though probably not by 8 weeks of treatment.

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