NIH Article Edition

NIH Article Edition

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Research Article

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Immune response to immunodominant Mycobacterium tuberculosis antigen ESAT6- derived peptide is HLA-haplotype dependent

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Michele Smart, Marshall Behrens, Luckey David, Catherine Conway, Veena Taneja

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The antigenic proteins of Mycobacterium tuberculosis (Mtb) have been defined. We used synthetic peptides of secreted antigens, early secreted antigenic target 6 (ESAT-6) and cultural filtrate protein-10 (CFP-10), of Mtb and characterized the immune response in context of HLA genes. Humanized mice lacking endogenous class II molecules but expressing various human DR and DQ HLA transgenes singly or as a haplotype were used to study the HLA-mediated immune response to peptides.