Nitric Oxide Metabolites (Nitrite and Nitrate) In Polycystic Ovary Syndrome
to vasodilation, attenuated release of endothelin-1 and thromboxane A2, inhibition of platelet aggregation, and inhibition of smooth muscle proliferation, and stimulation of endothelial cell proliferation/angiogenesis . In several clinical conditions the inducible NOS (iNOS) is hyperactivated and this event is especially associated with the increase of cytokines such as TNFα, IL-1β and interferon [7,8,9]. The activation of iNOS generates NO in the measure of up 1000-fold greater than nNOS or NOS . This accelerated NO synthesis has however an opposite effect because NO interacts with the superoxide anion (O2−) to produce peroxynitrite and other oxidants involved in tissue injury . NO metabolites (NOx), such as nitrite (NO2−) and nitrate
(NO3−), usually evaluated together and expressed as NOx may play a positive role in several clinical conditions. Some authors observed a significant positive association between NOx and inflammatory conditions (arterial hypertension, chronic kidney disease, metabolic syndrome, systemic sclerosis and in dialyzed and acute myocardial infarction subjects), which are associated with increased atherogenic risk .
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