Volume 1 Issue 4
Influence of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin on Bovine Herpesvirus 1 Replication
Filomena Fiorito*, Ugo Pagnini, Luisa De Martino and Giuseppe Iovane
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent member of the dioxin group of chemicals, herein called dioxin, is a toxic and persistent environmental contaminant. Humans and animals are generally exposed to dioxin which is incorporated in food, mainly in products of animal origin rich in fat, but also in drinking water, soil, dust, smoke and air. TCDD exerts most of its biochemical effects by binding to the Aryl hydrocarbon Receptor (AhR). AhR forms a complex with the AhR nuclear translocator (ARNT) protein by interactions with dioxin responsive elements and activates the expression of a battery of genes that catalyzes the metabolism and conjugation of xenobiotics.
Polymorphic variants of the P2X7 receptor in the domestic dog
Ronald Sluyter* and Leanne Stokes
Due to distinctive features including genome architecture, population diversity, breed structure and breed-specific disorders, the domestic dog (Canis familiaris) is becoming an important animal to study the genetics of morphology, behaviour and disease susceptibility in mammals. Further, with around 360 of the some 450 diseases in dogs similar to that of human diseases, dogs provide a valuable model to identify the genetic causes of many diseases in humans.