Prior Experience and Knowledge as Correlates of Parental Acceptance of HPV Vaccination

Prior Experience and Knowledge as Correlates of Parental Acceptance of HPV Vaccination

Corresponding author: Dr. Diane Reynolds, 1817 East 34th Street, Brooklyn, New York 11234, USA, Tel: 718 627-8127 (h); 718488-1655; (w); Fax: 718 780-4019; Email:



Although the advent of the Human Papillomavirus (HPV) vaccine holds the promise of preventing a major female reproductive cancer and genital warts, it is recognized that several factors may impact vaccine acceptance. Parental knowledge of HPV and its relation to cervical cancer, sources of HPV vaccine information, and prior experience with a sexually transmitted infection (STI) may contribute to attitudes toward this primary prevention effort.


The purpose of this study was to examine the relationship of factors contributing to knowledge of HPV and parental acceptance of HPV vaccination for their 9-18 year old daughters.


A descriptive correlational study was conducted using an online survey platform. The sample consisted of 323 parents/guard- ians of 9-18 year old daughters from the greater New York area.


Parental HPV vaccine acceptability was measured by 4-item Likert scale. Responses of those who had not had daughters vacci- nated (N = 218) were compared to responses of those (N = 105) that had already vaccinated their daughters against HPV. Those who did not intend to vaccinate were compared to those who intended to vaccinate.


There was a significant positive relationship between knowledge and prior experience; however, knowledge and prior experi- ence with HPV related diseases were not significant predictors of HPV acceptance.

Keywords: Human Papillomavirus; Parental Acceptance; HPV Knowledge; Prior Experience with HPV


HPV: Human Papillomavirus;

STI: Sexually Transmitted Infection


In June 2006, the Food and Drug Administration (FDA) licensed Gardasil® for use in girls and women 9–26 years of age [1]. This is the first vaccine developed to prevent cervical cancer and other diseases in females caused by certain types of geni- tal human papillomavirus (HPV). The main efficacy studies of the vaccine demonstrate nearly 100% effectiveness in prevent- ing cervical precancers, vulvar and vaginal precancers, as well as 90% vaccine efficacy in preventing genital warts. Over 99% of vaccinated girls in these studies developed antibodies after vaccination. Data indicate that the vaccine is effective, with no evidence of waning protection [2].

Successful vaccination programs are expected to substantially reduce the incidence of HPV infection, the incidence of HPV-as- sociated disease, and the economic as well as emotional bur- den related to HPV infection [3]. There is a tremendous op- portunity to prevent a female reproductive cancer through utilization of primary prevention tactics such as immunization. Parental acceptance of HPV vaccine may be critical in decreas- ing the incidence of cervical cancer, since parents are the pri- mary decision makers for child and adolescent immunization.

The purpose of this descriptive, correlational study was to ex- amine the relationship between parental knowledge of HPV and intention to vaccinate their 9-18 year old daughters. In ad- dition, this study examined the relationship between parental knowledge of HPV and vaccine status. This study also tested the hypothesis that parents who have had a personal history or know of someone who has had a sexually transmitted in- fection (STI) or cervical cancer will be more likely to intend to have their daughters receive HPV vaccination than parents who have not had a personal history or know of someone who has had a STI or cervical cancer. In addition, the relationship of these personal history variables to vaccine status was ex- amined.’

Knowledge of Diseases Associated With Human Papillo- mavirus

Misunderstanding and misconceptions about transmission of HPV, its role in cervical cancer, and the need for early vaccina- tion may hamper vaccine acceptability [4]. Despite the link be- tween HPV and cervical cancer, studies indicated that parents have limited knowledge regarding this association [5]. Over- all knowledge about HPV vaccine is inadequate [6]. A study of women’s knowledge regarding HPV infection, cervical can- cer, and HPV vaccines obtained via questionnaire by Giles and Garland [7] found that women had little knowledge regarding transmission or potential complications of HPV, such as cervi- cal cancer and genital warts.

Likewise, research on focus groups with 38 parents of 12-16 year olds conducted by Robbins and colleagues [8] revealed a

general lack of knowledge of what HPV is, how it is transmit- ted, and the HPV and cervical cancer connection. Focus groups conducted by Friedman and Shepeard [9] in 2007 found that HPV knowledge was low among participants; this lack of knowledge served as a barrier to vaccine acceptance, because participants did not know the prevalence or potential conse- quences of HPV.

The hypothesis that increased knowledge would lead to great- er vaccine acceptance was supported in several studies [10- 12]. Gerend, et al., [13], conducted a study examining respons- es to HPV vaccine acceptability and found that HPV vaccine knowledge was higher among the group of parents who had already vaccinated their daughter than those who had not vac- cinated their daughter. These results were in direct contrast to a cross-sectional, experimental study conducted by Dempsey, Zimet, Davis, and Koutsy [10] that found that despite an im- provement in knowledge scores in the experimental group, there was no significant difference with respect to vaccine ac- ceptability between study groups.

Prior Experience

Knowledge of HPV related diseases can be garnered through personal experience or vicariously through observation or in- teraction with others who have been infected with the virus. Having prior experience with HPV or related diseases may confer tacit knowledge of the virus. A parent’s prior experi- ence with cancer or a STI has been associated with greater HPV vaccine acceptability. Having been tested for HIV, having had cervical cancer or genital warts, and the belief that one’s child was at greater risk for an STI emerged as correlates of vaccine acceptance in several studies [14-18]. Zimet and col- leagues [19] conducted a cross-sectional study of 320 parents and their adolescent children, in order to identify predictors of STI vaccine acceptability. Parents in this study who reported a personal history of an STI were nearly four times more likely to be accepting of vaccination for their children than those par- ents who did not have a history of STI [19]. A larger study of 1,350 Canadian parents revealed that parents were more likely to intend that their daughters receive HPV vaccination if they thought someone they knew was likely to get cervical cancer [16].

Materials and Methods

Institutional Review Board (IRB) approvals were sought and obtained prior to conducting the study. A paper and pencil version of the questionnaire was pilot tested on a convenience sample of 9 subjects (XXX faculty members) in order to assess clarity of the questions and approximate time for comple- tion. An online version of the questionnaire was pilot tested on a convenience sample of 15 parents of females in the 8th grade of a local parochial school, in order to ensure clarity and ease of administration. Average time for completion of the

questionnaire was 15 minutes.. Parents (mother, father, or legal

guardian) of 9- to 18-year old female children were recruited for the study. Inclusion criteria were ability to read English and access to the internet. There were no exclusions due to age, race, or ethnicity. Survey Monkey was used to create an on- line survey. Participants were recruited via e-mail blasts sent to all those who hold a valid XXXX University e-mail account, providing them with a direct link to the survey, with follow-up reminders sent 4 and 8 weeks later. In an effort to intensify re- cruitment, an online Google advertisement was purchased. In addition, the researcher had the support of several local paro- chial grammar and high school principals who posted the sur- vey invitation on the parent-teacher website. Letters were also given to the children in grades 4 thru 8 to take home to their parents. The letter briefly described the purpose of the study and directed the parents to the survey. All responses were col- lected anonymously through an online platform. A comparison of the characteristics of respondents in other studies assessing parental attitudes towards HPV vaccinations indicated that the sample is reasonably representative and mirrored demograph- ic information reported in other quantitative HPV studies con- ducted in the United States, Canada, and the United Kingdom (U.K.) [6,10, 16, 18, 20-22]


A parent, in this study, is defined as a biological parent or guardian of a female child 9-18 years of age. For ease of read- ing, parents or guardians will be referenced as “parents” throughout the study. The majority of the respondents were female (97.4%), White (78.1%), married (71.7%), Catholic (63%), between the ages of 24-65 (mean 43.8). The sample was well educated with most having earned a Bachelor’s de- gree or higher (Table 1).

Age Mean




% N
Male 5.3 16
Female 94.7 288
Marital status
Divorced/widowed 10.9 33
Living with partner 5.6 17
Married 71.7 218
Separated, not divorced but living apart 5.3 16
Single 4.9 15
Prefer not to answer 2.6 8
Hispanic/Latino 7.9 24
White 78.1 218
Black or African American 11.5 32
Other (Asian, American Indian, Pacific 4.0 11
Islander) 10.5 30
Prefer not to answer
High school grad or GED 11.2 34
Some college 16.8 51
Associate’s degree 13.5 41
Bachelor’s degree 27.1 82
Master’s degree 22.4 68
Doctoral degree or higher 6.3 19
Prefer not to answer 2.3 7
Religious affiliation
Catholic 63.0 191
Christian (non-Catholic) 19.8 60
Jewish 5.6 17
None 5.6 17
Other 3.9 12
Prefer not to answer 2.0 6
Health Insurance
Have health insurance 96.0 291
Do not have health insurance 4.0 12
Child covered under health insurance 97.0 294
Child not covered under health insurance 3.0 9
Think health insurance plan covers HPV 66.3 201
vaccination 3.6 11
Health insurance plan will not cover HPV 30.0 91
Not sure if health insurance covers HPV

NB: Unaccounted percentage is missing demographic data.

Prefer not to answer was recoded as missing data.

One hundred and five had vaccinated their daughter against HPV while 218 had not. Responses from 323 were included in the final analysis. Sixty-seven potential respondents indi- cated that they did not have a daughter between the ages of 9-18 years of age and were precluded from continuing with the study. There were an additional 105 parents who did not complete all sections excluding them from the study.


A 108-item online questionnaire that assessed knowledge and additional factors that may contribute to vaccine accep- tance was administered to the respondent participants. Since research in the area of HPV vaccination is relatively new, few tools exist that measure issues surrounding parental accep- tance of the vaccine. As a result, two instruments were selected to assess the variables of interest. It should be noted that the knowledge items were taken from questionnaires that were administered before the vaccine was approved for use and psy- chometric properties were not previously reported for these items. Knowledge was assessed with a total of 14 items; seven were taken from a questionnaire created by Dempsey, Zimet, Davis, & Koutsky [10] in 2006, How do parents feel about new vaccines? An additional 6 items were taken from Parental views on vaccination questionnaire authored by Marlow, Waller, &, Wardle, ([22] with a final item that assessed knowledge (re- ceiving HPV vaccination means Pap smears will no longer be necessary) was developed for the current study. Prior experi- ence was assessed with 4 dichotomous items taken from the questionnaire by Dempsey and colleagues (2006) [10], that asked respondents if they or anyone close to them had expe- rience with HPV-related diseases, abnormal Pap smears, cervi- cal cancer, STI, or genital warts. Additional questionnaire items assessed other factors associated with parental acceptance or refusal of HPV vaccine such as concerns about safety, efficacy, promiscuity, and health provider recommendation not report- ed in this manuscript [23].

Because they were developed prior to the approval of HPV vac- cine, both instruments required subjects to respond to a hypo- thetical situation of intent to vaccinate. Therefore, a question was added about vaccine status by having participants indicate whether their child had or had not received the HPV vaccine. If the parent indicated that they had already vaccinated their child, they were able to skip the intent questions that followed. Four additional questions were developed for the current study that assessed the dependent variable, intention to vaccinate, with Likert scale responses definitely not (0), Probably not (1), Not sure (2), Yes probably (4), or Yes definitely (5). Respondents were categorized as non-intenders if they indicated “2” or less on the first question, “I intend to have my daughter receive the HPV vaccine.” Subsequent questions referred to the immedia- cy with which inte nt to vaccinate would be achieved. A “Not sure” response was coded as a non-intender, as there was no immediacy to their decision making. Analysis of the raw data

indicated that none of the respondents who answered the first question with a “2” or less, responded with a Yes probably (4), or Yes definitely (5) to subsequent questions, therefore, intent to vaccinate was dichotomized, based upon responses to the first question. Demographic information collected included age and gender of the parent, child’s age, marital status, race, level of education, religious affiliation, and insurance coverage for the child.



Parental knowledge of HPV and intent to vaccinate

The responses of 336 parents were considered in the analysis of the knowledge questions (Table 2). Eleven respondents exit- ed the questionnaire before indicating vaccine status and were not included in this analysis; therefore the final analysis was based on 325 responses. There were 142 non-intenders, 76 intenders, and 107 parents who had already vaccinated. Item discrimination analysis was conducted for all 14 of the knowl- edge questions. Items 4k and 4l were poor discriminators of knowledge based on that item analysis and were dropped. In- ternal consistency reliability estimated by Cronbach’s alpha for the remaining 12 items was .787. Further analysis was con- ducted on a total of 12 items.

Review of the percent response of each item, indicated that parents who had not vaccinated were not knowledgeable of HPV transmission or the consequences of being infected with the virus (Table 2). Logistic Regression is a statistical meth- od used to assess the association between independent vari- able(s) (Xi) — sometimes called exposure or predictor vari- ables —(knowledge) and a dichotomous dependent variable

(Y) — sometimes called the outcome or response variable (in- tent to vaccinate) [24] (Logistic regression analysis regressing intent of vaccinating on knowledge demonstrated that knowl- edge was not a statistically significant predictor of intent. Those who intended to vaccinate (n = 76) and those who had no intent to vaccinate (n = 142) had similar knowledge scores (mean = 8.72, 8.65 respectively).

Parental knowledge of HPV and vaccine status

One hundred and seven parents indicated that they had al- ready vaccinated their daughter against HPV. The mean knowl- edge scores for those parents who had already vaccinated their daughters were 8.78 (73%). These scores were similar to those of the group that had not vaccinated. Logistic regression analysis was conducted to compare differences in knowledge between the respondents who had already vaccinated their daughter and those who had not. Mean knowledge scores for parents who had already vaccinated (n = 107) were slightly higher (mean = 8.78 out of 12 points) than the group that did not vaccinated (n = 218) (mean 8.65) but this difference did not reach statistical significance.

Mean Standard Deviation Non-Intenders

n =142


n = 76

Already vaccinated n


Item Frequency






Q4a Genital warts are caused

by HPV 1

.4940 .50071 80 (56.%) 35 (46%) 48 (45%)
Q4b Condoms can prevent the

spread of HPV from person to person 1

.6518. .47711 49 (35%) 29 (38%) 36 (34%)
Q4c People who have been

infected with HPV might not have symptoms 1

.8333 .37323 23 (16%) 12 (16%) 18 (17%)
Q4d HPV infection can cause

abnormal Pap smears 1

.8274 .37848 24 (17%) 11 (14%) 19 (18%)
Q4e HPV is a sexually

transmitted disease 1

.7798 .41503 32 (23%) 16 (21%) 24 (22%)
Q4f HPV makes you unable to

have children 1

.5595 .49718 59 (42%) 30 (39%) 52 (49%)
Q4g Having an abnormal Pap

smear means you have cervical cancer 1

.9077 .28983 11 (8%) 9 (12%) 7 (6%)
Q4h Having many sexual partners increases the risk of

getting HPV 2

.8661 .34108 18 (13%) 10 (13%) 14 (13%)
Q4i HPV is related to the

AIDS virus 2

.6935 .46175 42 (30%) 24 (32%) 31 (29%)
Q4j HPV can be treated with

antibiotics 2

.5089 .50067 71 (50%) 34 (45%) 53 (50%)
Q4k HPV usually goes away without needing any treatment


.1399 .34738 124 (87%) 64 (84%) 92 (86%)
Q4l Most sexually active people will get HPV at some point in

their lives 2

.2976 .45789 101 (71%) 51 (67%) 76 (71%)
Q4m Men cannot

get HPV 2

.6250 .48484 54 (38%) 32 (23%) 34 (32%)
Q4n Receiving HPV vaccination means Pap smears

will no longer be necessary 3

.9077 .28983 12 (8%) 7 (9%) 8 (7%)

1Dempsey, Zim et, Davis, & Koutsky, [10] 2Marlow, Waller, &, Wardle, [22] 3Developed by Reynolds [23]

Non- Intender Already

Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4 Q4













Table 2. Knowledge questionnaire indicating percent correct/incorrect for each item N = 325.




n = 76



n=142 n = 107
Had Prior experience with

abnormal Pap smear

99 (69.7%) 56 (73.7%) 71 (66.4%)
Had Prior experience with 33 (23.2%) 23 (30.3%) 25 (23.4%)
cervical ca
Had Prior experience with STI 64 (45.1%) 33 (43.4%) 57 (53.3%)
Had Prior experience with

genital warts

40 (28.2%) 19 (25%) 37 (34.6%)

Prior Experience










Abnormal Pap

Cervical Ca


Genital Warts

non-intenders Intenders Already Vaccinated

Table 3. Frequencies of Prior experience for all groups.

Prior experience and intent to vaccinate

Prior experience was assessed by asking participants to re- spond to 4 questions with dichotomous choices about their own personal experience with an abnormal Pap smear, cervical cancer, a sexually transmitted disease, or genital warts, or knew of anyone close to them had these HPV related disorders.

A total of 218 respondents who had not yet vaccinated their daughters answered questions related to prior experience 1Dempsey, Zim et, Davis, & Koutsky, [10] 2Marlow, Waller, &, Wardle, [22] 3Developed by Reynolds [23]with 142 express- ing no intent to vaccinate, and 76 indicated intent to have their daughter vaccinated. The percentage of those who had experi- ence with cervical cancer was low overall, but higher for those who were intending to vaccinate (Table 3).

Prior experience and vaccine status

Comparison was made between those who had already vac- cinated and those who did not. Results indicated that a great- er percentage of those who had already vaccinated had prior experiences with a STI and genital warts. Those who had not vaccinated had more experience with an abnormal Pap smear than those in the vaccinated group (Table 4).

Logistic regression analysis was also conducted to test the relationship between prior experience and vaccine status for those who had already vaccinated (n = 107).

Logistic regression analysis was used to test the relationship between prior experience and intent to vaccinate.

B Std


β t p
Constant 7.482 .277 26.996 <.001
Prior experience with abnormal

Pap smear

1.467 .344 .245 4.266 < .001
Prior experience with cervical


-.697 .357 -.109 1.950 .052
Prior experience with STI .391 .343 .071 1.140 .255
Prior experience with genital


.641 .383 .106 1.675 .095

Dependent variable = knowledge Note R² = .097

Table 4. Regression Analysis for Knowledge and Prior Experience.

B Std. Error Beta t p
(Constant) 5.077 1.929 2.632 .009
Age Child -.019 .062 -.020 -.309 .758
Age parent -.010 .030 -.022 -.333 .740
Gender -.464 .760 -.037 -.610 .543
Marital status .185 .208 .054 .890 .374
Level of Ed. .522 .175 .182 2.983 .003
Religion -.681 .357 -.119 -1.908 .057
Child Health


2.850 1.123 .152 2.539 .012
Race .564 .420 .085 1.343 .180

Dependent var iable = knowledge R² = .085

Table 5. Regression Analysis for Demographics and Knowledge.

Prior experience with an abnormal Pap smear, cervical can- cer, a sexually transmitted disease, or genital warts was not a statistically significant predictor of intent to vaccinate for this group of respondents (Table 4)

Knowledge and Prior experience

A multiple linear regression was calculated for all respondents to determine the relationship of knowledge score to prior ex- perience. A significant regression equation was found (F (4,

323) = 8.069, p < .001), and accounted for 9.7% of the variance. Increased knowledge was related to having an abnormal Pap smear (Table 4). Prior experience with an abnormal Pap smear, cervical cancer, a sexually transmitted disease, or genital warts were not a statistically significant indicators when comparing those who had already vaccinated (n = 107) their daughter with those that had not (n = 218). Multiple regression analysis suggested that neither knowledge nor prior experience were predictive of intent to vaccinate or vaccine status.

Knowledge and demographics

A multiple linear regression was calculated for all respondents to determine the relationship of knowledge to demographic variables. A significant regression equation was found (F (8,

261) = 3.027, p .003), and accounted for 8.5% of the variance. Increased knowledge was related to health insurance for the child and having higher levels of education (Table 5).



The purpose of this study was to examine if a relationship existed among factors contributing to knowledge of HPV and parental acceptance of HPV vaccination for their 9 to18 year old daughters. Results of this study suggested that knowledge was not predictive of intent to vaccinate. Parents lacked knowl- edge of HPV, and approximately onequarter were not aware that HPV is a sexually transmitted disease. Although parents may have a general knowledge of HPV, it is possible that the respondents in this study did not have a firm understanding of the sequelae of HPV infection or genital warts. Perhaps these questions were not representative of the requisite knowledge parents required in order to make informed vaccine decisions. For instance, the set of knowledge questions in the survey did not assess if parents made the connection that the vaccine is most effective if given before sexual debut. This may be an im- portant piece of knowledge needed for decision making. The wide range of ages in the guidelines may contribute to confu- sion as to the optimal age of vaccination. The knowledge items in this study did not assess parents’ knowledge that the target population for the vaccine is 11 to 12 year olds. Several focus group discussions related to HPV have revealed that parents did not see the benefit of vaccination because their child was not currently sexually active [15,25,26]. Delaying vaccination may be based on parental reluctance to believe that their ad-

olescent daughter may be sexually active rather than knowl- edge related to the benefits the vaccine can afford if given prior to exposure to the virus. Perhaps if parents understood that vaccination before exposure to the HPV virus through sexual intercourse results in higher vaccine titers and may indicate longer lasting immunity, they may be more likely to accept vac- cination.

Vaccine acceptance despite low levels of knowledge and mis- conceptions about HPV was reported in a recent qualitative study by Robbins and colleagues [8]. Interestingly, although 107 respondents in this study indicated that they had already vaccinated their daughter, knowledge scores for this group were similar to those who had not vaccinated, suggesting that parents may accept HPV vaccination without having adequate levels of knowledge about the virus. These data are similar to findings from a 2009 correlational study conducted by Das and colleagues [27] that found no difference in the mean score on a knowledge test between people that did or did not consent to HPV vaccination for their child [27]. Parents may have differ- ing information needs which may range from simple to com- plex. Comprehensive understanding about vaccine character- istics may not be necessary for decision making.

Personal experience or knowing someone with HPV related diseases did not contribute to intent to vaccinate. These results contradict findings by previous researchers indicating that there was a relationship between prior experience with cervi- cal cancer, abnormal Pap smear or STI and vaccine acceptabil- ity [14-16,18]. In this current study, there was a significant re- lationship between personal experience or knowing someone who had experience with an abnormal Pap smear, or cervical cancer and knowledge, suggesting that experience in itself can be a source of knowledge. The current findings build upon pre- vious research and suggest that prior experience with HPV as- sociated diseases may contribute to knowledge but knowledge alone may not be sufficient to spur parents to vaccinate their adolescent daughters.

With the exception of age of the child, demographic variables did not predict intention to vaccinate nor did they play a role for those who had already vaccinated. Although demographics did not contribute to intent to vaccinate, having health insur- ance for the child and a higher education level were associated with knowledge. Cost of the vaccine (360.00 for the series of 3 injections) may be prohibitive for those who do not have insurance for their child. The relationship between having in- surance coverage and knowledge is unclear, but it is plausible that those who have health insurance may be more likely to receive more health related information from their insurance company.

In this sample, vaccine acceptance was poor; with 53.5% of parents who had not vaccinated their daughter against HPV indicated that they had no intent to do so. This proportion

included parents who were not sure about whether to vacci- nate, suggesting that there is a still a great deal of work to be done to uncover factors related to parental acceptance of this prophylactic vaccine.


Although the advent of the HPV vaccine holds the promise of preventing a major female reproductive cancer and genital warts, it is recognized that psychological and social barriers may compromise the effort. Parental acceptance is an import- ant area for research given that parents are in a position of authority over their minor children and as such are the main decision makers for whether their daughters should receive vaccine administration. Prior experience can be a source of knowledge. Knowledge alone is not an adequate stimulus for action. Further research is needed to identify parental con- cerns regarding HPV vaccination.


The results of this study may not be generalizable to parents living outside of the research recruitment area. A convenience sample of those who had access to the internet was used. Giv- en the nature of online recruitment, it is difficult to known how many individuals actually saw the Google advertisement. In addition, Catholic parents were oversampled in this study, which may have created a potential bias. Research should be done that is more inclusive of those from lower socioeconomic groups. Demographic data were missing for those who exited the survey before completion so a comparison on demograph- ic variables could not be made between those who completed and those who did not complete the questionnaire. The time consuming nature of answering a 108 item questionnaire may have contributed to responder fatigue. Although the reliabili- ty of the knowledge questions was acceptable the items that were selected for inclusion in this study may not be represen- tative of core knowledge competency.

Implications for Practice

The potential exists for cervical cancer rates to decrease but only if parents recognize the importance of vaccinating against Human Papillomavirus. The findings of this study offer health care providers and policy makers a greater understanding of parental knowledge or lack thereof in primary prevention ef- forts through HPV vaccination. The challenge is to understand parents’ perspective and to assist them in determining the benefit of preventative vaccination for their child. Conducting focus groups to uncover informational needs parents have may help develop knowledge items for future studies and frame rel- evant and meaningful HPV vaccine messages. Future research should address the type of information that parents are seek- ing. This may be achieved during small focus group sessions.

The type of knowledge parents possess may have changed based upon post-vaccine approval media campaigns and from the time this study was initially conducted. Comparing differ- ent educational approaches may serve to uncover which mes- sages are most effective in increasing knowledge of HPV. In turn, intervention studies that aim to increase vaccine uptake can be conducted. Health care providers, namely pediatricians, are the most likely proponents of vaccine information. Practi- tioners need to be aware that vaccine side effects such as syn- cope, nausea, headache, urticaria, redness, pain, and swelling at the injection site may impact parental decision making [28]. Further research could also include how pediatricians are framing recommendations and conveying knowledge to par- ents/guardians regarding HPV and its relationship to cervical cancer and other health related diseases.

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