Volume 1 Issue 2

Volume 1 Issue 2

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Review Article

Mitochondria and Vascular Sensitivity during Long-term Morphine Exposure

Hui Zhao*, Huilin Mou, Xiaojian Li, Han-Wei Huang

Microenvironment adaptation was proposed to be interoceptive cues for conditioned morphine dependence and tolerance. In the present study, we revealed in prefrontal cortex, that there was apparent mitochondrial and vascular oxidant production following long-term morphine treatment and subsequent naloxone precipitation. Comparably, naloxone precipitation equipped a higher capacity in modulation of VEGF-VEGFR2 signaling and close connection of VEGFR2 and AC5.

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Review Article

Molecular Chaperones Shape Steroid Receptor Action and Pharmacologic Strategies

Gisela I Mazaira, Mariana Lagadari, Alejandra G. Erlejman and Mario D. Galigniana*

Chaperone oligomers exist in cell cytosols as preassembled heterocomplexes that function as protein-folding molecular machines able to assemble essential proteins related to families that embrace steroid receptors, protein-kinases, ubiquitin- ligases, and transcription factors, among other families of key proteins. Actually, steroid receptors may be considered a particular subset of transcription factors that can be activated by specific ligands. Some of them are primarily located in the cytoplasm, others are constitutively nuclear, but regardless of their subcellular distribution, they are constantly shuttling between both compartments in a highly dynamic manner.

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