Volume 2 Issue 1
Variations in Concentration and Histological Distribution of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn in Nonhyperplastic Prostate Gland Throughout Adulthood
Vladimir Zaichick PhD DSc CChem FRSC*, Sofia Zaichick MD PhD
More than 70% the male population aged over 60 years has clinical or histologic evidence of benign prostatic hyperplasia (BPH), while prostate cancer (PCa) is the most common male non-cutaneous malignancy in the Western world. Understanding etiologies of both conditions is crucial to reducing the resulting burden of mortality and morbidity. The prevalence of BPH rises sharply with age. The prevalence of PCa also drastically increases with age, being three orders of magnitude higher for the age group 40–79 years than for those younger than 40 years. There are many similarities between the epidemiological factors of BPH and PCa but the greatest risk factor for both diseases is increasing age.
G-Protein Coupled Receptors (Rhodopsin-Like Receptors-Visual Signal)
G-protein coupled receptor is a multi-functional receptor that has numerous clinical implications. It is physiologically important in maintaining homeostasis, in particular via their ability to mediate responses to circulating hormones and neurotransmitter input in the central, peripheral and autonomic nervous systems. The cloning and characterization of GPCR and of components involved in mediating receptor responses and in regulating receptor expression has provided a number of new insights, because the ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis.