Volume 2 Issue 2

Volume 2 Issue 2

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Research Article

Influence of Thymoquinone on the Unfolding Transition of Human Serum Albumin

Zeyad J. Yasseen*, Jehad H. Hammad, and Hussein A. AL Talla

The effect of thymoquinone (TQ) on the conformational stability of human serum albumin (HSA) at different temperatures in the range of 25 – 50°C has been investigated by means of fluorescence spectroscopy. Urea induced unfolding transition of free and TQ-bounded HSA were characterized by fluorescence spectra and the results were analyzed using the linear extrapolation method (LEM), to characterize the effect of TQ binding on the conformational stability of HSA during the denaturation by urea. The unfolding profiles were shifted towards the higher urea concentration in presence of TQ., at lower temperatures.

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Review Article
Anti-Inflammatory Agents and their Role in Atherosclerosis
Timothy Allen, MD, Ph.D*, Giridhar M.N.V, MD,MBA*, Ghazaleh Shoja E Razavi MD

Atherosclerosis is a chronic disease, with the process of narrowing and hardening of arteries and accumulation of plaques. Normally, atherosclerosis is related with other cardiovascular disease such as peripheral vascular disease, heart attack, and stroke. Aninflammation plays a key role in the progression and development of atherosclerosis. Majorly dead cells and oxidized form of low density lipoproteins (oxLDL) are present as pro-inflammatory cytokines.

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