Volume 3 Issue 1
Response of the Bone Marrow Stromal Cells to Osteogenic Drugs in Patients Undergoing Primary Total Hip Arthroplasty
Weiping Ren*, Nancy Jackson, Jeffrey C. Flynn, and David C. Markel
Implant osseointegration relies on the interplay of implant surface and the surrounding bone cells. The purpose of this study was to investigate the in vitro response of the bone marrow stromal cells (BMSCs) to osteogenic drugs in patients undergoing primary total hip arthroplasty (THA). Bone marrow aspirates were obtained from the discarded femoral head in 13 THA patients. The number of STRO-1 and bone morphogenetic protein receptor (BMPR)-expressing cells were measured by flow cytometry. Real-time PCR was used to measure expression of osteogenic relevant genes of BMSCs.