Volume 3 Issue 1

Volume 3  Issue 1


Original Research Article

Functional Reconstruction of Turbinates with Growth Factors and Adipose Tissue in the Treatment of Empty Nose Syndrome

Lino Di Rienzo Businco, Alessia Di Mario*, Mario Tombolini*, Domenico Crescenzi**, Marco Radici**

Empty nose syndrome (ENS) is a devastating complication of turbinate surgery. The management of ENS is challenging and the evidence base for most treatment modalities remains low. In the present study we propose a safe and effective surgical reconstruction treatment based on the use of Platelet Rich Plasma mixed with Adipose tissue (PRL). The PRL is a preparation rich in stem cells and growth factors, taken from the same patient, that has the potential capability to regenerate the volume of the turbinate and to restore the functionality of the mucosa.

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Basic Research Article

Genetic Alterations Acquired During Culture Expansion of MSC Leads to Widespread Tissue Engraftment and Increased Differentiation Potential in Mice

Hanchen Li, Jian Hua Liu, Hao Zhang, Evelyn Kurt-Jones, Stephen Jones, JeanMarie Houghton*

Mesenchymal stem cells (MSC) are currently being tested as treatment for a variety of diseases. We have little information about the changes that occur during isolation and expansion, and the ultimate disposition of MSC in the body. We have shown that MSC isolated from the bone marrow of mice and expanded in culture undergo spontaneous mutations within oncogenes yet retain tri-lineage differentiation potential. Here we define the surface marker expression of these cells and compare it to the marker expression of previously isolated and characterized cultured pluripotent cells.

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