Volume 3  Issue 1

Volume 3  Issue 1

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Research Article

Effect of Gelatin Hydrogel Sponge Loaded with Bone Marrow Mesenchymal Stem Cells and Hepatocyte Growth Factor on Peripheral Nerve Regeneration

N. Sasaki*, J.P. Seo, H. Uchiyama, S. Haneda, K. Yamada, H. Furuoka, M. Itho, M. Yanagawa, Y. Tabata

Hepatocyte growth factor (HGF) can promote nerve cell proliferation. Gelatin hydrogel sponge can act as a scaffold for drug controlled release. . This study aimed to evaluate the beneficial effects of a gelatin hydrogel scaffold (sponge) loaded with BM-MSCs and HGF on radial nerve regeneration in a defect model. Twelve healthy calves (weighing 48.7 ± 5.54kg, mean ± S.D.) were used in this study. Stem cells were derived from bone marrow of ilium and cultured into culture dishes for two weeks. 1cm of the left radial nerve was defected under inhalation anesthesia.

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Research Article

Cyclical Shedding and Sustained anti-Phase 1 Antibody Responses in a Goat Herd Naturally Infected with Coxiella burnetii

Alicia D. Anderson*, Tahnee J. Szymanski, Kelly A. Fitzpatrick, Joshua S. Self, Rachael A. Priestley, William L. Nicholson, Gilbert J. Kersh

Coxiella burnetii is a worldwide zoonotic pathogen that can infect a variety of species and can cause Q fever in humans. Although an infected goat herd is a risk to human health, the duration of shedding and antibody responses in infected goats have not been clearly defined. In 2011, an outbreak of human Q fever in Washington and Montana was associated with infected goats, and one herd offered an opportunity for longitudinal sampling to investigate antibody responses and shedding of C. burnetii.

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