Volume 4  Issue 1

Volume 4  Issue 1

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Review Article

Albumins and Carotenoids of the Human Fetal Vitreous Body and their Morphogenetic Role during Midgestation
Ina G. Panova*, Alexander S. Tatikolov, and Olga G. Stroeva

The vitreous is a transparent, highly hydrated gel located between the lens and the retina. In the adult vitreous carotenoids are absent. At 15–28 weeks of gestation the molecular composition of human fetal vitreous is characterized by twenty fold increase in the albumin content as compared to that in the adult vitreous, and by the presence of two transitory molecules – lutein and alpha-fetoprotein. A strong correlation between the albumin and lutein concentrations was found. The organizing molecule of this complex is albumin. The morphogenetic roles of albumin, alpha-fetoprotein and lutein in the human eye development and physiology are discussed.

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Research article

Effect of Antiangiogenic Treatments about Biomarkers of Oxidative Stress in Patients with Age-Related-Macular Degeneration
Manresa N*, Mulero J, Losada M, Zafrilla P

Age-related macular degeneration (AMD) has become the leading cause of irreversible central vision loss in the elderly, affecting approximately 7.2 million people in United States over the age of 40 (6.5%). There are two main types of AMD: atrophy and neovascular. Neovascular AMD is characterized by the presence of choroidal neovascular membranes that are often associated with subretinal fluid, hemorrhage and eventually subretinal fibrosis with loss of vision.

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